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- Consider drug B from the example, assuming that doses are
given every six hours, or L=6. Compute the minimum initial dose
that will keep the concentration above the minumum effective
level for the first six hours, i.e before the second dose is given.
- Consider drug B from the example again, with doses to be given
every six hours. Can you find a dose such that the concentration
stays below M=8 and above m=1.8 for at least 48 hours?
- Suppose that new research on drug B indicates that the values of
M and m should be M=7 and m=2.5. Can you find values of
and L that produce a safe and effective treatment program? Try at
least two sets of values of and L. If your values don't work,
then can you suggest a way to change the treatment program to make it
safe and effective?
- Trials of another drug produced the following data. The
concentration just after the drug was administered was 6 mg/ml and 5
hours later the concentration was 2.88 mg/ml. If the maximum safe
concentration is 10 mg/ml and the minimum effective concentration is 2
mg/ml, find one set of values of and L that provide a safe and
effective treatment program. Make sure you justify your answers.
William W. Farr
Fri Feb 7 13:14:44 EST 1997