- Consider drug B from the example, assuming that doses are
given every six hours, or
*L*=6. Compute the minimum initial dose that will keep the concentration above the minumum effective level for the first six hours, i.e before the second dose is given. - Consider drug B from the example again, with doses to be given
every six hours. Can you find a dose such that the concentration
stays below
*M*=8 and above*m*=1.8 for at least 48 hours? - Suppose that new research on drug B indicates that the values of
*M*and*m*should be*M*=7 and*m*=2.5. Can you find values of and*L*that produce a safe and effective treatment program? Try at least two sets of values of and*L*. If your values don't work, then can you suggest a way to change the treatment program to make it safe and effective? - Trials of another drug produced the following data. The
concentration just after the drug was administered was 6 mg/ml and 5
hours later the concentration was 2.88 mg/ml. If the maximum safe
concentration is 10 mg/ml and the minimum effective concentration is 2
mg/ml, find one set of values of and
*L*that provide a safe and effective treatment program. Make sure you justify your answers.

Fri Feb 7 13:14:44 EST 1997