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- 1.
- Consider drug B from the example, assuming that doses are
given every three hours, or
*L*=3. Compute the minimum initial dose*C*that will keep the concentration above the minimum effective level for the first three hours, i.e before the second dose is given._{0} - 2.
- Consider drug B from the example again, with doses to be given
every three hours. Can you find a dose
*C*such that the concentration stays below_{0}*M*=8 and above*m*=1.8 for at least 48 hours? - 3.
- Suppose that new research on drug B indicates that the values of
*M*and*m*should be*M*=7 and*m*=2.5. Can you find values of*C*and_{0}*L*that produce a safe and effective treatment program? Try at least two sets of values of*C*and_{0}*L*. If your values don't work, then can you suggest a way to change the treatment program to make it safe and effective? - 4.
- Trials of another drug produced the following data. The
concentration just after the drug was administered was 6 mg/ml and 5
hours later the concentration was 2.88 mg/ml. If the maximum safe
concentration is 10 mg/ml and the minimum effective concentration is 2
mg/ml, find one set of values of
*C*and_{0}*L*that provide a safe and effective treatment program. Make sure you justify your answers.

1/31/1998